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KMID : 0363320060270010253
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 1 p.253 ~ p.264
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Effects of Jujadokseo-hwan on Mice with Alzheimer’s Disease Induced by Amyloid-{beta}
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Kyung Hyuk-Su
Ko Heung
Leem Kang-Hyun
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Abstract
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Object: This research investigated effects of Jujadokseo-hwan on mice with Alzheimer’s Disease induced by amyloid-{beta}. According to Dongyibogam, Jujadokseo-hwan can cure amnesia. Amyloid-B is believed to induce oxidative stress and inflammation in the brain, postulated to play important roles in the pathogenesis of Alzheimer’s disease. In this way Amyloid-{beta} induces Alzheimer’s Disease.
Methods : In order to make an efficient prescription and cope with dementia, learning and memory functions of mice were tested on passive avoidance test and V-maze task. NF-{kappa}B were measured from protein derived from the brain. RT-PCR was done for !gene analysis. Primers were protein kinase Band NGF-{alpha}.
Results :
1. Jujadokseo-hwan was effective for memory capacity on passive avoidance test. but noneffective for spatial memory capacity and locomotor activity on Y -maze task.
2. The measurement of NF-{kappa}B showed upward tendancies and the result of RT-PCR showed up-regulation when given Jujadokseo-hwan by mouth.
Conclusion: Results suggest that Jujadokseo-hwan is effective on mice with Alzheimer’s Disease induced by amyloid-{beta}.
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KEYWORD
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amyloid-{beta}, Jujadokseo-hwan, Alzheimer’s Disease, memory, learning
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